(Millar et al., 2000). Further genetic association studies support an expanded role of DISC1 in influencing risks for schizophrenia, bipolar disorders, major depression, and autism (Chubb et al., 2008). To understand how DISC1 dysfunction contributes to a broad spectrum of mental disorders, it is important to clarify biological function and signaling mechanisms of DISC1 in the normal brain. While recent studies have begun to delineate DISC1 intracellular signaling mechanisms (Chubb et al., 2008), very little is known about how DISC1 interacts with specific extracellular signaling to control different aspects of neuronal development in vivo.
