include syntaxin binding protein 1 (Stxbp1) on chromosome 2 and sodium channel, type IV, (Scn4b) on chromosome 9, among many others, including some mentioned above. A significant development corresponding with the ability to examine the expression of thousands of genes at a single time is the move toward more comprehensive analyses of gene networks (Mulligan et al. 2006; Green et al. 2007; Kerns and Miles 2008; Song et al. 2009). Genetic perturbation of interconnected pathways regulated by multiple genes is more likely than are large major gene effects to explain genetic components for complex alcohol use disorders and even seemingly simpler traits used to model aspects of excessive drinking.
