plausible that the smaller case-control sample was sufficiently powered to detect the association signal. Notwithstanding these possibilities, our results with current smoking need careful replication and currently should be viewed with some caution. A number of emerging genomewide association studies (GWAS) may provide clues. To date, we are not aware of any GWAS that has implicated polymorphisms in GABRA2 – however, the candidate genes component of the NICSNP GWAS (Bierut et al., 2007; Saccone et al., 2007) reported evidence for association with GABRA4 with follow-up analyses also finding considerable support for the role of GABRA2 (data not shown).
