Our signature matching technique used data from the Library of Integrated Network-based Cellular Signatures (LINCs) L1000 database64. The LINCs L1000 database catalogues in vitro gene expression profiles (signatures) from thousands of compounds in over 80 human cell lines (level 5 data from phase I: GSE92742 and phase II: GSE70138)26. We selected compounds that were currently FDA approved or in clinical trials (via https://clue.io/repurposing#download-data; updated 3/24/20). Our analyses included signatures of 829 chemical compounds (590 FDA approved, 239 in clinical trials) in five neuronal cell-lines (NEU, NPC, MNEU.E, NPC.CAS9 and NPC.TAK), a total of 3,897 signatures were present as not all compounds were tested in all cell lines in the LINCs dataset.
