FTND and CPD included in the mediation model is 2.73 (1.34–5.53) 0.005, and the pseudo-r2 is 0.083. rs1051730 is significantly and positively associated with CPD and with FTND score (p<0.001 and p=0.016, respectively). FTND score is significantly negatively associated with 6MO abstinence (OR=0.71, 0.57–0.89, p=0.003), while CPD is non-significantly negatively associated with 6MO abstinence. The effect of rs1051730 on 6MO abstinence excluding both nicotine dependence measures from the model is 2.23 (1.12–4.44) 0.022, with pseudo-r2 of 0.058. Thus, rs1051730 has a stronger relation with 6MO abstinence when the dependence measures are included in the model than when they are not, i.e., that the dependence measures are acting as suppressors in this mediation model [72].
