The introduction of ChIP-seq and ChIP-chip technologies enables the detection of de novo transcription factor binding sites and changes in histone modifications in mammalian genomes. Efforts such as the ENCODE project supply a large compendium of this type of data. To identify the exact location of protein-DNA binding, genomic regions with statistically enriched reads, called peaks, are detected. The final step in such analyses is to associate peaks with genes. The updated version of Enrichr features similar functionality developed for the popular tool Genomic Regions Enrichment of Annotations Tool (GREAT) (33) by allowing users to upload BED files describing genomics region peaks. A Java module in Enrichr maps the chromosome coordinates listed in input BED files to their nearest coding mouse or human genes. User options allow the specification of whether the input is for human or mouse, and the number of genes to return based on distance to the transcription start site (TSS). The identified nearest genes are automatically uploaded to Enrichr for enrichment analysis. Enrichr now has a new button that enables users to view, cut and paste
