In the present study, seven subjective responses to alcohol were measured prior to and during a 3-hour IV alcohol infusion during which BrAC was held steady at 60 mg/dL; a placebo, saline infusion, session was also conducted in counterbalanced order. We hypothesized that alleles in GABRA2 and GABRG1 previously shown to be associated with alcohol-related risk phenotypes would also be associated with acute adaptation of the subjective response to alcohol during the clamped steady-state interval. We also tested if this association was affected by recent drinking history, family history of alcoholism, or gender.
