Individuals with TD/CTD were statistically significantly more likely to have a first-degree relative with any AD (Table 2). The effect was highest among mothers of individuals diagnosed with TD/CTD (40% increased risk), followed by fathers (31% risk) and siblings (17% risk), but CI overlapped. Furthermore, second- and third-degree relatives of individuals with TD/CTD did not have a significantly elevated risk of AD (Table 2). Family-level analyses of individual AD followed the same general pattern (Supplementary Table 3).
