To evaluate the influence of potential confounds, group differences were examined in an ANCOVA (N = 72). Specifically, lifetime cigarettes smoked, Fagerstrom Test for Nicotine Dependence score, lifetime other drug use instances, and parental history of SUD were greater in MJ+ALC users than controls. Group differences in FA and MD reported above persisted after controlling for these variables (F(12,54) = 6.50, p <.001). Mean FA and MD did not relate to estimated premorbid IQ or gender in either group.