of first-degree relatives (identified using PREST [22]). No second degree relatives were detected. For this study, the test set for the PLCO prostate cancer study consisted of 1,171 prostate cancer cases and 1,094 controls while the test set for the NHS breast cancer study included 1,140 breast cancer cases and 1,138 controls. Four combinations of cases and controls were analyzed: PLCO cases vs. PLCO controls (PLCOca-PLCOco), NHS cases vs. NHS controls (NHSca-NHSco), PLCO cases vs. NHS controls (PLCOca-NHSco), and NHS cases vs. PLCO controls (NHSca-PLCOco).
