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Chunk #45 — Review

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Genome-wide association studies in ADHD.
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Although none of the findings were genome-wide significant, interesting candidate genes for ADHD are reported in this paper, too. Of the 80 top-ranked SNP findings, 30 fall into genes, of which nearly all are known to be expressed in brain (see Table 3). A second list, containing the top-10 of those genes with 3 or more SNPs among the 1,000 highest-ranking findings contains the genes KALRN (15 SNPs), ZNF354C (15 SNPs), WRNIP1 (14 SNPs), GRB10 (10 SNPs), DPP6 (7 SNPs), ARHGAP22 (11 SNPs), RAB38 (11 SNPs), FAT3 (8 SNPs), DA259379 (13 SNPs), NT5DC3 (20 SNPs). A third list summarizes all findings that show overlap with the linkage analysis in adult ADHD patients published earlier by the same group (Romanos et al. 2008), and in some instances also a family-based GWAS based on the 50 K linkage dataset (Table 3 in Lesch et al. 2008). Of the 30 genes listed there, 8 genes (CTNNA2, MOBP, MAP1B, REEP5, ASTN2, ATP2C2, CDH13 and ITGAE) overlap with the list of the 80 top-ranked SNP findings, as indicated in Table 3. The authors highlight the