The proportion of individuals with age at onset before 14, 18 and 25 years of age and peak age at onset for diagnostic spectra (co-primary outcome measures) are reported in Table 1. Overall, before age 14, 18, and 25 years, a disorder had already emerged in 34.6%, 48.4%, and 62.5% of individuals (Table 1).Table 1Meta-analytic epidemiological estimates of age at onset of mental disorder (ICD-11 blocks highlighted in italics) in the general population.No of SamplesPeak age at onset (years)Proportion onset by 14 yearsProportion onset by 18 yearsProportion onset by 25 yearsp25Medianp75Any mental disorder1414.534.6%48.4%62.5%111834Neurodevelopmental disorders215.561.5%83.2%95.8%71216Autism spectrum disorder25.572.4%89.8%94.8%5914Attention deficit hyperactivity disorder129.556.8%73.0%91.8%81218Anxiety and fear-related disorders735.538.1%51.8%73.3%91725Specific phobia/separation anxiety disorder225.572.4%75.0%80.4%5817Social anxiety disorder4214.550.9%79.1%87.5%91317Panic disorder2215.58.2%22.5%45.7%182636Generalised anxiety disorder2415.58.6%20.4%33.0%203242Obsessive-compulsive related disorders2014.524.6%45.1%64.0%141929Obsessive-compulsive disorder2014.524.6%45.1%64.0%141929Feeding or eating disorders1115.515.8%48.1%82.4%151823Anorexia nervosa815.518.2%55.2%78.7%141722Bulimia Nervosa815.516.0%45.3%82.9%151822Binge eating disorder519.512.3%34.5%73.5%162025Trauma-related disorders1615.516.9%27.6%43.1%173048Post-traumatic stress disorder1615.516.9%27.6%43.1%173048Disorders due to substance use or addictive behaviours5819.52.9%15.2%48.8%202541Disorder due to use of cannabis1019.53.2%17.5%64.6%192229Disorder due to use of alcohol4419.54.2%18.3%44.8%192743Schizophrenia-spectrum and primary psychotic disorders3620.53.0%12.3%47.8%202534Schizophrenia2520.52.0%8.2%47.4%212535Acute and transient psychotic disorder218.51.8%6.6%20.6%273545Personality disorders620.51.9%9.6%47.7%202533Mood disorders7920.52.5%11.5%34.5%213146Depressive disorders6219.53.1%13.2%36.9%213044Bipolar or related disorders4019.55.1%13.7%32.0%223349p25, p75, 25th and 75th percentile. Only the earliest peaks are shown. Different metric on the same sample has been extracted from multiple studies.
