Chromatin remodeling complexes have not been viewed as a drugable target until recently, but our work shows that the BRG1 chromatin remodeling enzyme is an especially promising target for epigenetic breast cancer chemotherapy (28, 59, 85). Inhibition of BRG1 function decreases tumor cell proliferation, decreases tumor mass in mouse models, and potentiates tumor cell killing by clinically used chemotherapy drugs.
