The fundamental nature of mental disorders remains poorly understood, but genetic factors have an important role.1, 2, 3, 4, 5, 6, 7 Considerable progress in psychiatric genetics has been made in recent years, based on large samples and international collaborations, for example, through the pivotal efforts of the Psychiatric Genomics Consortium.8 We can expect that larger samples will reveal new insights to common and rare variants underpinning mental disorders.9