Alcohol use was an important cause of disease burden in most of Latin America. It was ranked first in central Latin America, fourth in tropical Latin America, and sixth in Andean Latin America in 1990, and first in all these regions in 2010. Risk factors for childhood communicable disease had been largely replaced by those causing non-communicable diseases in these regions by 2010, although household air pollution from solid fuels was still an important risk factor in Andean Latin America in 2010.