exposed to ethanol, miR-9 up-regulation altered the relative expression of splice variants of the alpha subunit of the large conductance calcium- and voltage-activated potassium (BK) channel (Kcnma1), thereby favoring the expression of BK isoforms resistant to ethanol-induced potentiation [86]. Systematic investigation of genome-wide effects of ethanol on miRNA expression in the adult brain has recently provided novel insights into the regulation of protein-coding gene expression in the context of chronic ethanol exposure.
