Rgs7, a member of the RGS (regulator of G-protein signaling) family, is another high-ranking candidate in Qrr1d. RGS proteins are important regulators of G-protein mediated signal transduction. Rgs7 is predominantly expressed in the brain and has been implicated in regulation of neuronal excitability and synaptic transmission [97],[98]. Although RGS proteins are usually localized in the plasma membrane, RGS7 has been found to shuttle between the membrane and the nucleus [99]. This implies a role for RGS7 in gene expression regulation in response to external stimuli.
