the results presented here may only be applicable to middle- to older-aged white British individuals. Considering that genetic influences on alcohol consumption change across the life course,71 the variants identified in this study may have limited relevance outside of this demographic. It is important to note that the mean weekly alcohol consumption for males in this sample was 20.8 units per week, almost 6 units higher than the UK Chief Medical Officers’ recommendation of 14 units per week for men and women. This suggests that among this demographic, males are regularly consuming levels of alcohol that could cause risks to health.
