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Chunk #28 — DISCUSSION

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Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II/III pyramidal neurons.
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reduction of thalamic afferents to the cortical layer III after postnatal alcohol exposure was demonstrated previously (Granato et al., 1995); suggesting modifications to the thalamic filter which result from postnatal alcohol exposure. The current study adds to the previous reports that suggest alterations to the thalamic filter may occur not only in thalamic afferents but also in the neurons to which they project.