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Chunk #0 — Methods and Materials — Sample

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MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma.
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Participants included 114 children: 73 children who were removed from their parents’ care within the past 6 months because of reports of abuse or neglect (or both), and 41 community control subjects demographically matched for low socioeconomic status, with no history of maltreatment or exposure to intrafamilial violence. This sample represents a subset of children included in our prior study examining genetic and environmental predictors of depression (20),with this subsample restricted to children with teacher ratings of aggression (80% of the sample) and female subjects homozygous for MAOA genotype. As is depicted in Table 1, several prior reports included women who are heterozygous for MAOA, although it is unclear whether the MAOA gene escapes X-inactivation, as has been postulated (21). It is therefore impossible to determine what proportion of each allele is expressed in heterozygous females, which is why they were not included in this report.