Even indices of alcohol consumption, such as lifetime maximum drinks in 24 hours and monthly alcohol use, were more closely related to the genetic liability indexed by AUDIT-P PRS than AUDIT-C PRS. However, this difference was most notable in COGA, for which drinking for at least 6 months during the lifetime represents a highly heterogeneous group of individuals, which may include both non-problem drinkers and those with AUD. As expected, and in line with prior studies (Mies et al., 2018; Sanchez-Roige et al., 2018), AUDIT-P outperformed AUDIT-C for measures of problem drinking within each sample (i.e., COGA, ALSPAC, GS and UKB; see Table 2), confirming that the AUDIT-P is more closely related to genetic susceptibility to alcohol misuse than AUDIT-C.
