The rate of alcohol-induced deaths, largely due to alcoholic liver disease, increased substantially among men and women in the United States from 2000 to 2016, especially in more recent years. Rates increased throughout the study period among AIAN men and women, white men and women, API men and women, and Latina women. Although declines occurred among black women from 2000 to 2007, black men from 2000 to 2012, and Latino men from 2000 to 2013, these promising trends reversed course, and rates of alcohol-induced mortality increased from 2013 to 2016 in all examined racial/ethnic groups.