The exception to this was CHRNA7, which is a member of the Gene Ontology (GO) categories “cation channel activity” (GO:5261; case CNV hits enrichment p=0.0184, GWAS enrichment p=0.042), “channel regulator activity” (GO:16247; p=0.0307, p=0.026), and “regulation of tumor necrosis factor production” (GO:32680; p=0.0088, p=0.014). CHRNA7 was affected by six duplications in case subjects but none in comparison subjects (p=9.08×10–4) and had a Simes-corrected gene-wide p value of 0.0002 from the GWAS.
