Some of our top SNPs and genes were located in or near genes previously associated with other psychological traits, but none were directly related to personality. Our top genes did not overlap more than expected by chance with known functional molecular pathways. Furthermore, none of our top SNPs corresponded with the top SNPs in Terraciano et al. (2008), Shifman et al. (2008) and van den Oord et al. (2008) for overlapping Big Five/Eysenck scales (e.g., Harm Avoidance and Neuroticism, Novelty seeking and Extraversion); indeed, none of the top SNPs in those studies were even nominally significant (p < .05) in our data. This strongly reinforces the conclusion that, individually, common genetic variants do not contribute substantively to variation in personality.
