Chunk #33 — Online Methods — PolyFun fine-mapping method

Source

Functionally informed fine-mapping and polygenic localization of complex trait heritability.

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yes

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PolyFun first estimates prior causal probabilities for all SNPs and then applies fine-mapping methods such as SuSiE21 or FINEMAP22,23 with these prior causal probabilities. Here we describe estimation of the prior causal probabilities.