On the other hand, CTRP3 is highly expressed in both osteoscarcoma and chandroblastoma cell lines but not in the MC3T3-E1 mouse osteoblast-like non-cancer cell line (3). These data have led to speculation that elevated CTRP3 level in adults may be a risk factor and/or biomarker for certain types of cancer, specifically osteoscarcoma, but again this hypothesis remains to be tested either in vivo or in a clinical population.
