PTSD is a common and debilitating condition influenced by genetic factors, yet common genetic risk variants for PTSD have not been robustly identified. The PGC-PTSD combined data from 60 multi-ethnic cohorts (PGC1.5) and the UK Biobank (PGC2) achieved a sample size of 206,655 participants with 32,428 PTSD cases, over ten times that of any previous analysis10,25. As has been demonstrated in GWAS of SCZ23, BPD26, and recently in MDD18,27 and ADHD20, sample size is critical to produce robust genome-wide significant hits that inform foundational knowledge on the neurobiology of complex psychiatric conditions. These results show this is also true of PTSD. This increased power has led us to draw several major conclusions.
