The diagonal elements of VSLDSC can be estimated using the jackknife resampling procedure in the bivariate version of LDSC that is currently available by its original developers.4,43 The LDSC function introduced in the GenomicSEM software package expands the jackknife procedure to the multivariable context in order to additionally produce sampling covariances (which index dependencies among estimation errors) among the elements of SLDSC, needed to populate the off-diagonal elements of VSLDSC.
