DGIdb 3.0 has undergone significant changes. The number of drug–gene interactions and druggable genome definitions has been substantially expanded through the updating of existing sources and inclusion of new sources. To improve searches, we have included preset filters that allow searches for commonly requested gene or drug classes. To utilize these filters, a more intuitive UI was created and new fields to the database schema were added. Additionally, there are new ways to both access the data within the DGIdb and to deploy local or cloud instances of the database.