of Alzheimer’s disease brains identified an increased aggregation of insoluble U1 snRNP, a small nuclear RNA (snRNA) component of the spliceosomal complex, suggesting that the core splicing machinery may be altered in Alzheimer’s disease12. Apart from these studies, there have been few investigations of the possibility of more widespread splicing disruption affecting brain transcriptomes in Alzheimer’s disease13. However, a comprehensive study of cis- and trans- acting genetic factors that regulate alternative splicing in aging brains is lacking.
