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Chunk #32 — DISCUSSION

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Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.
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the two studies might be due, not only to differing definitions of affecteds, but also the definition of unaffecteds. Finally, the current study did not identify the same SNPs as were noted in our prior study of ANYDEP and its quantitative equivalent in a much smaller subset of these data (N=1,170 – 2,183; Supplemental Table S7), which is not uncommon with the substantially increased sample size used here.