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Chunk #5 — Introduction

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Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip.
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Knowledge of study power is also invaluable when analysing data from a study. Assessment of whether positive results at a particular significance level are “real” or due to chance requires knowledge of power [5], and the practical decision of how far down the list of potential associations one should go in replication studies should be informed by power considerations.