factor model (the Addiction-Risk-Factor) (Hatoum et al., 2023) to the data using genomic structural equation modeling (SEM). Finally, we tested whether a polygenic score (PGS) for DSM-NicDep was associated with DSM-5 tobacco use disorder and its 11 diagnostic criteria and 4 of the 6 FTND criteria in a large, independent sample – the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) cohort.
