To demonstrate the high resolution of our datasets, we annotated the striatal interneuron using previously characterized mouse markers of these subtypes108. We sub-clustered the interneurons labeled by the macaque dataset and annotated them manually as interneuron subtypes best labeled by the marker genes TH, PTHLH, SST, or CCK. The previously published macaque snRNA-seq dataset had too few of these interneurons sampled from N = 2 monkeys, so these subtypes were under-represented to be sub-clustered. In this study, we sampled more broadly from N = 12 individuals (human) or N = 8 individuals (rhesus macaque). While these interneuron subtypes are clearly distinct in this dataset and in the neural circuits, they still are under-represented to power certain downstream. For these analyses, we analyze these cells together as “Interneurons”.
