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Chunk #7 — Methods — Existing methods — Generalized estimating equations (GEE)

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An efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function.
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studies have conducted simulations to investigate whether GEE can control the type I error rate when multivariate traits are involved in GWAS. To fill in this knowledge gap, we conduct a simulation study to examine the statistical properties of this approach. In this study, we only consider the identity link because we are mainly interested in continuous phenotypic traits. We also assume the working correlation matrix to be compound symmetry because it only requires us to estimate one additional parameter.