with mild-to-moderate AUD either endorsing no high-risk criteria or at least 1 high-risk criterion were classified into low-risk (n = 2486) and high-risk (n = 993) groups, respectively. Low-risk mild-to-moderate, high-risk mild-to-moderate, and severe AUD groups were then compared across alcohol-related, psychiatric, and EEG correlates using mixed-effects logistic and linear regression models fitted using the lme4 package (version 1.1-30)33 in R controlling for sex, age, self-declared race and ethnicity, and criterion count. Criterion count was included as a covariate given our combined grouping of mild and moderate AUD and our goal to examine associations independent of or not simply due to individual differences in the number of criteria endorsed. Mixed-effects models adjusted for familial clustering. Similar analyses, conducted separately by genetic ancestry, were used to examine associations between AUD PGS and diagnostic groups (eMethods in Supplement 1).
