In conclusion, the A/A genotype in the KCNJ6 A1032G SNP and −1250G/1032A haplotype were significantly associated with increased analgesic requirements after major open abdominal surgery. Furthermore, KCNJ6 gene expression levels in the 1032A/A subjects was significantly decreased compared with the 1032A/G and 1032G/G subjects. Although the association might be restricted to the Japanese population, and the mechanism by which individual sensitivity to postoperative analgesics is altered by the G-1250A and A1032G SNPs remains to be fully elucidated, the outcome indicates that the A1032G SNP and G-1250A/A1032G haplotype could serve as markers that predict increased analgesic requirements. Our findings will provide valuable information to better modulate individual analgesic dosages required to achieve satisfactory pain control and open new avenues for personalized pain treatment.
