(defined here as “non-malignant lung tissue”) to minimize the potential for local cancer field effects. Transcriptome sequencing of 90 non-tumor samples was performed on the Illumina HiSeq2000/2500 platform with 100-bp paired-end reads. Genotyping was undertaken using Illumina bead arrays as described previously. (iii) GTEx: eQTL summary statistics based on RNAseq analysis were obtained for eQTL summary statistics from the GTEx data portal http://www.gtexportal.org/home/35. This data included 278 individuals with data from lung tissue. Details of these three eQTL studies are included in the Supplementary Note.
