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Chunk #86 — III. Selected Methodological Issues — A. Genotyping using pooled DNAs

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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3. Number of different replicate samples: Power calculations assess the likelihood that an experiment can detect a difference of a certain magnitude in a specific SNP. Experiments require reasonable levels of protection against false-positive results, α. They also require reasonable power, β. Genome wide association requires many repeated measures; considerations of α and β thus need to be applied to hundreds of thousands or millions of SNPs.