SNPs in an independent sample of nearly 2000 EAs using TaqMan genotyping or GoldenGate custom array. Two SNPs located in the first intron of TLL1 were significantly associated with PTSD with p values 6.3×10−6 and 2.3×10−4. Combining the GWAS and replication sample, rs6812849 reached genome-wide significance with a p value of 3.1×10−9 and rs7691872 had a p value of 1.2×10−7. These two SNPs in TLL1 were also replicated in subjects with trauma exposure, but the association did not reach genome-wide significance in the combined samples. The two SNPs on 7p12 were not replicated. No genome-wide significant SNPs were observed in AAs.
