We profiled AUD-associated differences in gene expression and chromatin accessibility in different cell types, the biological pathways underlying these differences, and AUD-associated differences in transcription factor activity and cell-cell communication in major glial cell types (Fig. 1). This study provides a comprehensive profile of AUD-related differences in the caudate nucleus and identifies potential mechanisms of AUD and novel directions for further exploration. Our novel experimental approach highlights the broader utility of large-scale multiomic studies for identifying regulatory mechanisms, which can be applied to other neurological and psychiatric conditions.
