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Chunk #50 — Methods — Simulations

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An atlas of genetic correlations across human diseases and traits.
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We simulated quantitative traits under an infinitesimal model in 2062 controls from a Swedish study. To simulate the standard scenario where many causal SNPs are not genotyped, we simulated phenotypes by drawing causal SNPs from 622,146 best-guess imputed 1000 Genomes SNPs on chromosome 2, then retained only the 90,980 HM3 SNPs with MAF above 5% for LD Score regression.