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Chunk #29 — BACKGROUND — The first ENIGMA‐OCD brain structural connectivity results

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An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
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After conducting the initial meta‐ and mega‐analyses of regional brain volumetric abnormalities, we initiated analyses of structural brain connectivity, using both structural covariance graph analyses (Yun et al., 2020) and diffusion tensor imaging (Piras et al., 2019). Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation, as well as common effects of a disorder (Hunt et al., 2016). Large‐scale investigation of structural covariance networks are therefore of specific interest when studying neurodevelopmental disorders such as OCD that have chronic symptoms over the lifespan.