functions including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, protein ubiquitination and degradation63 and has also been associated with primary open-angle glaucoma.64 BTBD3 is expressed in the brain, with the highest observed levels in childhood and adolescence (www.BrainSpan.org, Release 3),63 when OCD frequently emerges.65 rs6131295 is a cis-eQTL for BTBD3 in the frontal cortex (p=0.028), a region that has repeatedly been implicated in OCD. This SNP is also a parietal cis-eQTL for ISM1 (20p12;p=0.0036) and an LCL trans-eQTL for DHRS11 (17q11.2;p=0.0001).
