Chunk #1 — Introduction

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Absolute quantification of somatic DNA alterations in human cancer.

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Measuring somatic copy number alterations (SCNAs) on a relative basis is straightforward using microarrays 1,2,3,4,5 or massively parallel sequencing technology 6,7; it has been the standard approach for copy-number analysis since the development of comparative genomic hybridization (CGH) 8.