As shown in Table 1, the old version of WebGestalt only supported seven gene identifiers from a few public databases for human and mouse, including Entrez Gene ID, Gene Symbol, RefSeq for DNA, RefSeq for protein, Unigene, Ensemble ID and Uniprot ID. In contrast, the new version of WebGestalt not only supports identifiers from more public databases but also recognizes identifiers from major high-throughput platforms for human and seven important model organisms including mouse, rat, worm, fly, yeast, dog and zebrafish. Using human as an example, WebGestalt has increased the number of identifiers from public databases to 13. Meanwhile, WebGestalt has added 35, 4, 5 and 1 identifiers from Affymetrix, Agilent, Illumina and Codelink microarrays, respectively. Although identifiers from gene expression arrays are typically supported by enrichment analysis tools, those from SNP arrays are less well supported. It is increasingly recognized that pathway-based enrichment analysis can greatly complement the single-SNP-based analysis in understanding genetic determinants of common diseases and providing insights into the pathway dysregulation of complex diseases (13,14). WebGestalt has added 21 identifiers from commonly used human SNP array
