The chemical nature of the constituents of Cannabis sativa is diverse, with the number of natural compounds totaling 565 [1,6]. Among these, 120 cannabinoids have been isolated and classified into 11 general types, of which, the best known and the most studied are Δ9-trans-tetrahydrocannabinol (THC), and cannabidiol (CBD). THC, first reported by [2], is considered the principal psychoactive component, whereas CBD, first reported by [7], is recognized as a major non-psychotropic constituent of Cannabis sativa [8]. The discovery of these components was followed by the identification of their presumed targets through the cloning of specific cannabinoid receptors. Consequently, the endogenous ligands to these receptors were found in the brain, and called endocannabinoids (eCB), which triggered enormous progress in the exploration of their physiological importance, as well as the relevance of cannabis and its products in many health conditions including mental health [9,10,11].
