Prepulse inhibition of the acoustic startle response was used as a measure sensorimotor gating. Prepulse inhibition occured when a low pre-stimulus of varying intensity (20 ms duration; 74, 78, 82, 86, and 90 dB) was given 100ms prior to a louder startle stimulus (40 ms duration; 120 dB), diminishing the response to the louder stimulus. Mice were tested with a San Diego Instruments SR-Lab system as described previously (Moy et al., 2006; Paylor and Crawley, 1997). The peak startle amplitude during a 65-msec period beginning with the startle stimulus was measured. Each test session consisted of forty-two trials, following a five-minute habituation period.
