From the discovery 23andMe dataset we identified two distinct regions containing SNPs with p-value < 1×10−8 and five additional loci with p-value < 5×10−8 (Supplementary Table 1) to be associated with self-report of depression. We have chosen to consider only the SNPs with pval < 1×10−8 to be genome-wide significant in this GWAS due to correction for 15 million SNPs in the 23andMe data. The most significant locus yielded an association at rs2806933 (adjusted p-value= 8.53×10−13, OR= 0.955, 95% CI= 0.943–0.968 effect allele frequency in controls= 0.61) in a region spanning the 3′ UTR for the olfactomedin-4 gene (OLFM4), not previously implicated in neuropsychiatric disease but known to be expressed in brain, including amygdala and medial temporal lobe7. The second, with peak association at rs768705 (p-value= 2.91×10−12, OR= 1.051, 95% CI= 1.036–1.067, effect allele frequency in controls= 0.25), spans a locus containing the myocyte enhancer factor 2C (MEF2C) and transmembrane protein 161B (TMEM161B) genes. Variants in MEF2C has been previously associated with multiple CNS phenotypes including epilepsy and intellectual disability8,9 and implicated in regulation of synaptic function10. TMEM161B, also brain-expressed,
