Nest building behavior assessed social behavior. Without drug treatment, fGluN1 control mice consistently formed an identifiable nest in a new cage from all of the provided cotton nestlet. In contrast, KO mice showed a robust deficit at both 12 and 16 weeks, and PWSI exacerbated their impairment (Figure 2F). Interestingly, APO reduced the amount of unused nestlet to a similar level as the group-housed KO mice.
